M?LL? MÜCADELE DÖNEM?NDE S?LVAN KAMUOYU

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite similar expression at the mRNA level from the wild-type and chimeric MLL alleles, the chimeric protein is more stable. We report that UBE2O functions in regulating the stability of wild-type MLL in response to interleukin-1 signaling. Targeti...

MLL Gene Alterations in Acute Myeloid Leukaemia (11q23/MLL+ AML)

Classical Logic = Fibred MLL

Syntactically, classical logic decomposes thus [Gir87]: Classical logic = MLL + Superposition where MLL is Multiplicative Linear Logic, and superposition means contraction (binary case) and weakening (nullary case). Proof nets for classical logic have been proposed [Gir91, Rob03], containing explicit contraction and weakening nodes. Just as the logical sequent rules of conjuction (tensor) and d...

Applying MLL to ILP∗

In Inductive Logic Programming (ILP), since logic is a complete (universal) language, infinitely many possible hypotheses are compatible (hence plausible) given the evidence. An intrinsic way of selecting the most convenient hypothesis from the set of possible theories is not only useful for model selection but it is also useful for guiding the search in the hypotheses space, as some ILP system...

MLL-r Leukemia

25 years ago the HTRX, HRX, ALL-1, MLL gene, now renamed to KMT2A, has been discovered at chromosome 11q23 and shown to be rearranged with two different genes, AF4 and ENL, due to balanced chromosomal translocations. These two chromosomal translocations discovered in the labs of Carlo Croce and Michael Cleary-were the starting point for a new field of research associated with acute leukemia [1,2].